Cancer cell. More...

#include <cell.hpp>

Public Member Functions
	Cell ()=default
	Default constructor.

	Cell (const coord_t &v, unsigned i, std::shared_ptr< EventRates > er=std::make_shared< EventRates >()) noexcept
	Constructor for first cells.

	Cell (const Cell &other) noexcept
	Copy constructor.

	~Cell () noexcept=default
	Destructor.

Cell &	operator= (const Cell &)=delete
	Copy assignment operator.

	Cell (Cell &&other)=default
	Move constructor.

Cell &	operator= (Cell &&)=default
	Move assignment operator.

std::string	mutate (urbg_t &)
	driver mutation

std::string	force_mutate (urbg_t &)
	driver mutation on all traits

double	delta_time (urbg_t &, double now, double positional_value, bool surrounded=false)
	Calc dt and set next_event_.

void	differentiate (urbg_t &)
	Change proliferation_capacity_ stochastically.

void	set_time_of_birth (double t, unsigned i, const std::shared_ptr< Cell > &ancestor) noexcept
	Set time_of_birth_; reset other properties.

void	set_cycle_dependent_death (urbg_t &, double death_prob)
	Set event_rates_->death_prob and next_event_.

void	increase_death_rate () noexcept
	Increase event_rates_->death_rate to birth_rate() for simulating Moran-like situation.

bool	is_differentiated () const noexcept
	Check proliferation_capacity_.

Setter functions
void	add_coord (const coord_t &direction) noexcept
	Add to coord_.

void	set_coord (const coord_t &v) noexcept
	Set coord_.

void	set_coord (coord_t &&v) noexcept
	Set coord_.

void	set_time_of_death (double t) noexcept
	Set time_of_death_.

Getter functions
static param_type	PARAM_
	Parameters shared among instances.

std::shared_ptr< Cell >	ancestor_
	pointer to the ancestor

std::shared_ptr< EventRates >	event_rates_
	Set of event rates (copy-on-write)

double	time_of_birth_ = 0.0
	time of birth

double	time_of_death_ = 0.0
	time of death

coord_t	coord_ = {}
	Position in a tumor.

unsigned	id_
	ID.

int8_t	proliferation_capacity_ = -1
	\(\omega\); stem cell if negative

Event	next_event_ = Event::birth
	next event: birth, death, or migration

double	birth_rate () const noexcept
	Get EventRates.birth_rate.

double	death_rate () const noexcept
	Get EventRates.death_rate.

double	death_prob () const noexcept
	Get EventRates.death_prob.

double	migra_rate () const noexcept
	Get EventRates.migra_rate.

Event	next_event () const noexcept
	Get next_event_.

const coord_t &	coord () const noexcept
	Get coord_.

std::ostream &	write (std::ostream &ost) const
	TSV.

std::ostream &	traceback (std::ostream &ost, std::unordered_set< unsigned > *done) const
	Write TSV while tracing back ancestor_ recursively.

static std::string	header ()
	TSV header.

static void	param (const param_type &p)
	Set PARAM_.

static const param_type &	param ()
	Get PARAM_.

std::ostream &	operator<< (std::ostream &, const Cell &)
	Stream operator for debug print.

Detailed Description

Cancer cell.

The documentation for this class was generated from the following files:

Public Types